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The information contained in this publication is intended for healthcare professionals and students. Categories presented in Clinical Evidence indicate a judgement about the strength of the evidence available to our authors prior to publication and the relevant importance of benefit and harms. We rely on our authors to confirm the accuracy of the information presented to describe generally accepted practices. Readers should be aware that professionals in the field may have different opinions. Because of this fact and because of regular advances in medical research we strongly recommend that readers independently verify specified treatments and drugs including manufacturers' guidance. Also, the categories do not indicate whether a particular treatment is generally appropriate or whether it is suitable for a particular individual. Ultimately it is the reader's responsibility to make their own professional judgements, and to appropriately advise and treat their patients. Opinions posted on Clinical Evidence are those of the individuals and not the views of the BMJ Publishing Group Ltd ('BMJ Group').

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